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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methylprednisolone

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 30/08/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Corticosteroids, systemic (oral, parenteral)
5

Publications

Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2021 Jul 13;17;70 2021 Jul 13
Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy.
Italian journal of pediatrics 2017 Nov 17;43;104 2017 Nov 17
Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.
The journal of allergy and clinical immunology. In practice 2014;2;471-4 2014
Methylprednisolone-induced anaphylaxis: diagnosis by skin test and basophil activation test.
Allergy 2010 Apr;65;531-2 2010 Apr
Allergic reactions after intravenous injection of methylprednisolone: A case report.
Korean journal of anesthesiology 2009 Oct;57;499-502 2009 Oct
Severe hypersensitivity reactions to corticosteroids in children.
Pediatric emergency care 2009 May;25;339-41 2009 May
Clinical evaluation of anaphylactic reactions to intravenous corticosteroids in adult asthmatics.
Respiration; international review of thoracic diseases 2002;69;309-13 2002
Methylprednisolone anaphylaxis.
The American journal of emergency medicine 1999 Oct;17;583-5 1999 Oct
Anaphylactic shock induced by intraarticular injection of methylprednisolone acetate.
The Journal of rheumatology 1997 Jun;24;1191-4 1997 Jun
[Severe anaphylactoid reactions after intravenous corticosteroids. Report of a case and review of the literature].
Therapie 1990;45;505-8 1990
Anaphylaxis after intravenous corticosteroid administration.
The Journal of emergency medicine 1986;4;213-5 1986

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