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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methyldopa

2

XII.d Myocarditis (can be fulminant)

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Myocarditis and methyldopa.
Acta medica Scandinavica 1982 May;211;233-5 1982 May
Fatal methyldopa-associated granulomatous hepatitis and myocarditis.
The American journal of the medical sciences 1982;283;41-5 1982
Drug related myocarditis. I. Hypersensitivity myocarditis.
Human pathology 1981 Oct;12;900-7 1981 Oct
Myocarditis associated with methyldopa therapy.
JAMA 1977 Apr 18;237;1699-701 1977 Apr 18

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