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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

XIII.k Lymphoproliferative disease (extrathoracic)

1
Last update : 13/02/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.
Auris, nasus, larynx 2019 Dec;46;927-933 2019 Dec
Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities.
American journal of respiratory and critical care medicine 2019 Apr 15;199;1031-1033 2019 Apr 15
Methotrexate-Related Lymphoproliferative Disorder Presenting with Severe Swelling of the Elbow Joint: A Case Report.
JBJS case connector 2017;7;e65 2017

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