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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

2
Last update : 13/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

[Fatal pneumonitis during low-dose methotrexate treatment].
Zeitschrift fur Rheumatologie 2012 Jan;71;75-7 2012 Jan
Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.
The European respiratory journal 2000 Feb;15;373-81 2000 Feb

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