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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

XIII.g Lymphomatoid granulomatosis (pulmonary, endothoracic)

1
Last update : 15/02/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Successful treatment of methotrexate-associated classical Hodgkin lymphoma with brentuximab vedotin-combined chemotherapy: a case series.
International journal of hematology 2020 May;111;667-672 2020 May
A surgical case of methotrexate-associated lymphomatoid granuloma.
General thoracic and cardiovascular surgery 2018 Jul;66;435-438 2018 Jul
Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis.
Minerva anestesiologica 2014 Jan;80;119-20 2014 Jan
Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis.
SpringerPlus 2014;3;751 2014
Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.
Clinical rheumatology 2007 Sep;26;1585-9 2007 Sep

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