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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

XVII.e Pneumocystis jiroveci pneumonia

2
Last update : 06/04/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors.
Modern rheumatology 2012 Nov;22;849-58 2012 Nov
Pneumocystis jirovecii infection: an emerging threat to patients with rheumatoid arthritis.
Rheumatology (Oxford, England) 2012 Dec;51;2120-30 2012 Dec
Pulmonary coinfection by Pneumocystis carinii and Aspegillus fumigatus in a seronegative arthritis patient treated with low-dose methotrexate.
Clinical rheumatology 2004 Dec;23;555-6 2004 Dec
Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.
Thorax 1991 Dec;46;936-7 1991 Dec
Severe pneumonitis occurring during methotrexate therapy. Re- port of two cases.
Archives of dermatology 1971 Feb;103;194-7 1971 Feb

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