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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

1
Last update : 18/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

[Fatal pneumonitis during low-dose methotrexate treatment].
Zeitschrift fur Rheumatologie 2012 Jan;71;75-7 2012 Jan
Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.
The European respiratory journal 2000 Feb;15;373-81 2000 Feb
Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.
Annals of hematology 2000 Dec;79;696-9 2000 Dec
Lung disease associated with methotrexate therapy.
Australian and New Zealand journal of medicine 1974 Jun;4;277-80 1974 Jun
Methotrexate-induced pulmonary disease.
Journal of the Canadian Association of Radiologists 1973 Sep;24;215-20 1973 Sep

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