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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

I.w Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

1
Last update : 16/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Comment on methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis.
Arthritis and rheumatism 2003 Aug 15;49;617; author reply 617-8 2003 Aug 15
Fatal pulmonary fibrosis complicating low dose methotrexate therapy for rheumatoid arthritis.
The Journal of rheumatology 1995 Sep;22;1766-8 1995 Sep

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