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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

VIII.a Angioedema (may cause UAO, asphyxia and death)

1
Last update : 01/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Angio-neurotic oedema associated with methotrexate treatment in rheumatoid arthritis.
Rheumatology (Oxford, England) 1999 Sep;38;908 1999 Sep
Anaphylactoid reactions to methotrexate.
Cancer 1996 May 15;77;2123-6 1996 May 15

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