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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Methotrexate
5
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
3
Last update :
13/02/2016
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
Pemetrexed
Publications
Anaphylactoid reaction to high-dose methotrexate and successful desensitization.
A rare drug reaction to methotrexate after treatment for ectopic pregnancy.
Anaphylactoid reactions to methotrexate.
Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate.