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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methotrexate

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

3
Last update : 13/02/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
DMARDs (disease-modifying antirheumatic drugs)
5
Pemetrexed
3

Publications

Anaphylactoid reaction to high-dose methotrexate and successful desensitization.
Pediatric blood & cancer 2010 Sep;55;557-9 2010 Sep
A rare drug reaction to methotrexate after treatment for ectopic pregnancy.
Obstetrics and gynecology 2004 May;103;1047-8 2004 May
Anaphylactoid reactions to methotrexate.
Cancer 1996 May 15;77;2123-6 1996 May 15
Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate.
Cancer 1978 Jan;41;52-5 1978 Jan

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