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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methimazole

2

XI.n Neutropenia, agranulocytosis (w/wo infection/sepsis)

1
Last update : 04/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Antithyroid drug-induced agranulocytosis complicated by pneumococcal sepsis and upper airway obstruction.
Internal medicine (Tokyo, Japan) 2013;52;2355-9 2013
[Pulmonary aspergillosis due to methimazole-induced neutropenia: a case report].
Revista peruana de medicina experimental y salud publica 2012 Jun;29;255-8 2012 Jun
Delayed anithyroid drug-induced agranulocytosis.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012;18;e69-72 2012

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