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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methadone

5

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 30/08/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Methadone, inhaled
1
Opiates - Opioids - Opium
5

Publications

Prevalence of pulmonary edema among the deceased cases with acute Methadone poisoning: A report from Iran.
Journal of research in pharmacy practice 2016;5;290-293 2016
Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.
European radiology 2014 Jun;24;1276-82 2014 Jun
Extracorporeal membrane oxygenation as rescue therapy for methadone-induced pulmonary edema.
Pediatric emergency care 2011 Jul;27;633-4 2011 Jul
[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].
Presse medicale (Paris, France : 1983) 2011 Apr;40;436-8 2011 Apr
Toxicology and pathology of deaths related to methadone: retrospective review.
The Western journal of medicine 2000 Jan;172;11-4 2000 Jan
Nonfatal pulmonary edema after "freebase" cocaine smoking.
The American review of respiratory disease 1987 Jul;136;179-81 1987 Jul
Methadone-induced pulmonary edema.
Canadian Medical Association journal 1975 Nov 22;113;966-7 1975 Nov 22
Pulmonary edema and adult respiratory distress syndrome following methadone abuse.
The American review of respiratory disease 1973 Jun;107;1047-51 1973 Jun
Methadone pulmonary edema.
Chest 1973 Feb;63;275-6 1973 Feb

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