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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methadone

5

XI.r Death following exposure or poisoning

2
Last update : 29/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Methadone, inhaled
1
Opiates - Opioids - Opium
5

Publications

Methadone overdose in patients following methadone mainte- nance treatment:A three years overview in the district of Bari (South-Italy).
La Clinica terapeutica 2021 May 05;172;247-249 2021 May 05
Therapeutic and recreational methadone cardiotoxicity.
Journal of forensic and legal medicine 2016 Apr;39;80-4 2016 Apr
Evaluation of poly-drug use in methadone-related fatalities using segmental hair analysis.
Forensic science international 2015 Mar;248;134-9 2015 Mar
Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.
European radiology 2014 Jun;24;1276-82 2014 Jun
Prognostic factors in acute methadone toxicity: a 5-year study.
Journal of toxicology 2014;2014;341826 2014
Contributing factors to methadone-related deaths in Ontario.
The American journal of forensic medicine and pathology 2010 Dec;31;313-9 2010 Dec

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