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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Methadone
5
XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
2
Last update :
30/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Methadone, inhaled
Opiates - Opioids - Opium
Publications
Prognostic factors in acute methadone toxicity: a 5-year study.
Treatment of methadone-induced torsades de pointes with lidocaine.
Methadone deaths: risk factors in pain and addicted populations.