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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methadone

5

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

2
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Methadone, inhaled
1
Opiates - Opioids - Opium
5

Publications

Prognostic factors in acute methadone toxicity: a 5-year study.
Journal of toxicology 2014;2014;341826 2014
Treatment of methadone-induced torsades de pointes with lidocaine.
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 2013;165;338-41 2013
Methadone deaths: risk factors in pain and addicted populations.
Journal of general internal medicine 2010 Apr;25;305-9 2010 Apr

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