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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Metamizole

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 29/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

[Intraoperative bronchospasm during paranasal sinus surgery -- indicator of aspirin intolerance syndrome?].
Laryngo- rhino- otologie 2006 Jun;85;415-20 2006 Jun
Drug-induced bronchospasm: analysis of 187 spontaneously reported cases.
Respiration; international review of thoracic diseases 2001;68;345-51 2001

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