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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Mefloquine
1
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
1
Last update :
14/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Malaria prophylaxis
Publications
Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.
Mefloquine-induced eosinophilic pneumonia.
Mefloquine-induced pneumonitis.
[Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].
Pulmonary toxicity of malaria prophylaxis.