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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mefloquine

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 14/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Malaria prophylaxis
2

Publications

Mefloquine-induced eosinophilic pneumonia.
Pharmacotherapy 2007 Dec;27;1767-71 2007 Dec
Mefloquine-induced pneumonitis.
Journal of travel medicine 2006;13;172-4 2006
[Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2005 Feb;43;103-7 2005 Feb
Pulmonary toxicity of malaria prophylaxis.
BMJ (Clinical research ed.) 1988 Nov 12;297;1240-1 1988 Nov 12

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