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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amphotericin B (infusion)

3

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 06/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1997 May;16;364-8 1997 May
The physiologic effects of inhaled amphotericin B.
Chest 1995 Sep;108;750-3 1995 Sep
Rapid infusion amphotericin B: effective and well-tolerated therapy for neutropenic fever.
Pharmatherapeutica 1989;5;305-11 1989

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