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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Medroxyprogesterone

1

I.w Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

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See PMID 2994878

Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Fatal pulmonary toxicity by the association of radiotherapy and medroxyprogesterone acetate.
Cancer 1985 Nov 15;56;2434-6 1985 Nov 15

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