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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Losartan

2

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 07/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Treatment of angiotensin receptor blocker-induced angioedema: A case series.
The Laryngoscope 2015 Jul;125;1619-23 2015 Jul
Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.
The American journal of cardiology 2012 Nov 15;110;1552-3 2012 Nov 15
[Angioedema due to losartan].
Medicina clinica 2011 Sep 10;137;281-2 2011 Sep 10
Losartan associated anaphylaxis and angioneurotic oedema.
JPMA. The Journal of the Pakistan Medical Association.. 2010 Aug;60;685-6 2010 Aug
Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.
Pharmacotherapy 2002 Sep;22;1173-5 2002 Sep
Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology.
The Laryngoscope 2001 Oct;111;1729-31 2001 Oct
Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.
The Annals of pharmacotherapy 2000 Apr;34;526-8 2000 Apr
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema.
The Annals of pharmacotherapy 1998 Oct;32;1060-6 1998 Oct
Angioedema induced by the angiotensin II blocker losartan.
The New England journal of medicine 1995 Dec 07;333;1572 1995 Dec 07

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