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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lomustine (CCNU)

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Carmustine (BCNU)
3
Fotemustine
1
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7;552-60 2001
[Nitrosourea-induced lung diseases].
Revue des maladies respiratoires 1992;9;575-82 1992
The pulmonary toxicity of nitrosoureas.
Pharmacology & therapeutics 1989;41;443-60 1989
The nitrosoureas and pulmonary toxicity.
Cancer treatment reviews 1981 Jun;8;111-25 1981 Jun

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