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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lisuride

2

V.c Pleural thickening - Fibrothorax

1
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ergots, ergot alkaloids, ergolines
4

Publications

Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis.
Clinical neuropharmacology 2006;29;80-6 2006
Pleuropulmonary disease associated with dopamine agonist therapy.
Annals of neurology 1991 Oct;30;613-6 1991 Oct

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