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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lipids (parenteral)

3

II.b ARDS - Acute lung injury

1
Last update : 06/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Parenteral nutrition
2

Publications

The impact of intravenous fat emulsion administration in acute lung injury.
American journal of respiratory and critical care medicine 2004 Mar 01;169;638-44 2004 Mar 01
Microvascular pulmonary emboli secondary to precipitated crystals in a patient receiving total parenteral nutrition: a case report and description of the high-resolution CT findings.
Chest 1999 Mar;115;892-5 1999 Mar
Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study.
BMJ (Clinical research ed.) 1998 Aug 08;317;379-84 1998 Aug 08
Fat overload syndrome causing respiratory insufficiency.
Journal of pediatric surgery 1984 Dec;19;777-8 1984 Dec

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