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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lidocaine (lignocaine, xylocaine)

3

XIV.a Methemoglobinemia

3
Last update : 12/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anesthetic agents (local, topical)
3
Xylocaine
3

Publications

Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Pediatric dermatology 2016 Sep;33;e284-5 2016 Sep
Lidocaine-induced methemoglobinemia: a clinical reminder.
The Journal of the American Osteopathic Association 2015 Feb;115;94-8 2015 Feb
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Annales de dermatologie et de venereologie 2012 Dec;139;824-7 2012 Dec
Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures.
Local and regional anesthesia 2011;4;25-8 2011
Application of topical analgesia in triage: a potential for harm.
The Journal of emergency medicine 2008 Jul;35;39-41 2008 Jul
Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.
Journal of medical case reports 2008 Jan 23;2;16 2008 Jan 23
Severe methemoglobinemia from topical anesthetic spray: case report, discussion and qualitative systematic review.
CJEM 2001 Jan;3;51-6 2001 Jan
Severe methemoglobinemia following dental extractions under lidocaine anesthesia.
Anesthesiology 1956 Jan;17;204 1956 Jan

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