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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lidocaine (lignocaine, xylocaine)

3

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

1
Last update : 29/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anesthetic agents (local, topical)
3
Xylocaine
3

Publications

Bronchospasm and anaphylactic shock following lidocaine aerosol inhalation in a patient with butane inhalation lung injury.
Allergy, asthma & immunology research 2011 Oct;3;280-2 2011 Oct
Adrenaline through the endotracheal tube as an answer to severe bronchospasms caused by lidocaine.
Minerva anestesiologica 2010 Jan;76;63-5 2010 Jan
Acute bronchospasm following administration of lidocaine.
Anesthesia & pain control in dentistry 1993;2;203-5 1993

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