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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Leuprorelin - Leuprolide
1
I.b
Pneumonitis (ILD)
-
Last update :
27/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Androgen deprivation therapy (Antiandrogens)
Triptorelin
Publications
Interstitial pneumonitis associated with leuprorelin acetate for a prostate cancer: A case report.
Interstitial pneumonitis secondary to leuprorelin acetate for prostate cancer.
Interstitial pneumonitis induced by bicalutamide and leuprorelin acetate for prostate cancer.
Interstitial pneumonitis related to leuprorelin acetate and flutamide.
Interstitial pneumonitis associated with neoadjuvant leuprolide and nilutamide for prostate cancer.
[Acute respiratory distress syndrome after injection of leuprorelin].
