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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XV.i Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)

1
Last update : 14/12/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.
The New England journal of medicine 1981 Sep 03;305;539-45 1981 Sep 03

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