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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

1
Last update : 11/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone-induced systemic lupus erythematosus.
The Journal of the Association of Physicians of India 2003 Feb;51;216-7 2003 Feb
Drug-induced lupus erythematosus by amiodarone.
Archives of internal medicine 2002 Apr 08;162;834-6 2002 Apr 08
Amiodarone induced lupus.
Annals of the rheumatic diseases 1999 Oct;58;655-6 1999 Oct

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