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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XVIII.b Eye catcher: Electron-dense area or areas of consolidation on unenhanced chest CT

2
Last update : 03/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone-induced hepatic and pulmonary toxicity.
Postgraduate medical journal 2018 Oct;94;603 2018 Oct
An enlarged heart with hyperdense consolidation.
The Netherlands journal of medicine 2013;71;317, 321 2013

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