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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 11/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

New-onset bronchial asthma induced by low-dose amiodarone.
The Annals of pharmacotherapy 2005 Feb;39;385-6 2005 Feb
Two cases of bronchial asthma after treatment with amiodarone.
Pacing and clinical electrophysiology : PACE 2001 Oct;24;1563-5 2001 Oct
Exacerbation of bronchial asthma following treatment with amiodarone. Demonstration of an antiadrenergic effect in vitro.
Chest 1984 Sep;86;492-4 1984 Sep

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