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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XI.f Bluish, pseudocyanotic skin discoloration

1
Last update : 02/01/2014
 
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Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone induced "Blue man syndrome"; an unusual presentation.
Heart & lung : the journal of critical care 2020;49;202-203 2020
Blue Woman Syndrome and Thyrotoxicosis in a Patient on Amiodarone.
European journal of case reports in internal medicine 2020;7;001526 2020
[The "blue man"].
Orvosi hetilap 2013 Dec 22;154;2043-7 2013 Dec 22
Amiodarone-induced facial pigmentation.
British journal of hospital medicine (London, England : 2005) 2012 Aug;73;473 2012 Aug
Pulmonary masses in a patient with blue-gray cutaneous hyperpigmentation.
European review for medical and pharmacological sciences 2008;12;113-6 2008
Images in cardiovascular medicine. The blue man: amiodarone-induced skin discoloration.
Circulation 2006 Feb 07;113;e63 2006 Feb 07
[The face in not only coloured by blue blood].
Pneumologie (Stuttgart, Germany) 2005 Aug;59;533 2005 Aug
[What is your diagnosis? Pseudocyanosis due to amiodarone].
Praxis 2004 Oct 13;93;1725-6 2004 Oct 13
A case of pseudocyanotic coloring of skin after prolonged use of amiodarone.
International journal of cardiology 2003 Aug;90;345-6 2003 Aug
Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation.
Clinical cardiology 1996 Jul;19;592-4 1996 Jul

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