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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

2
Last update : 14/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Organizing pneumonia secondary to amiodarone treatment.
Heliyon 2022 Sep;8;e10630 2022 Sep
Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.
The American journal of surgical pathology 2012 Apr;36;509-16 2012 Apr
Amiodarone lung toxicity in a cardiac transplant candidate initially diagnosed by fine-needle aspiration: cytologic, histologic, and electronmicroscopic findings.
Diagnostic cytopathology 2006 May;34;351-4 2006 May
Bronchiolitis obliterans organising pneumonia secondary to amiodarone treatment.
The Netherlands journal of medicine 1998 Sep;53;109-12 1998 Sep
Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.
Thorax 1989 Sep;44;711-5 1989 Sep

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