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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

2
Last update : 09/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone-induced multiple organ damage in an Alström syndrome patient with end-stage renal disease and hepatic cirrhosis.
CEN case reports 2022 Feb;11;11-16 2022 Feb
A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report.
Military medicine 2012 Jan;177;118-20 2012 Jan
Severe amiodarone induced pulmonary toxicity.
Journal of thoracic disease 2012 Dec;4;667-70 2012 Dec
Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.
The American journal of surgical pathology 2012 Apr;36;509-16 2012 Apr
Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.
Chest 1992 Sep;102;980-1 1992 Sep
Amiodarone pulmonary toxicity.
Ultrastructural pathology 1984;6;199-207 1984
Diffuse alveolar damage syndrome associated with amiodarone therapy.
Canadian Medical Association journal 1983 May 15;128;1192-5 1983 May 15
Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug.
Circulation 1982 Apr;65;819-24 1982 Apr

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