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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

3
Last update : 11/05/2012
 

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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone toxicity and the acute respiratory distress syndrome.
QJM : monthly journal of the Association of Physicians 2019 Nov 01;112;880-881 2019 Nov 01
Rapid onset of amiodarone induced pulmonary toxicity after lung lobe resection - A case report and review of recent literature.
Annals of medicine and surgery (2012) 2017 Sep;21;53-57 2017 Sep
Early Amiodarone-Induced Pulmonary Toxicity after Endovascular Aneurysm Repair: A Case Report.
The International journal of angiology : official publication of the International College of Angiology, Inc 2016 Sep;25;189-92 2016 Sep
Amiodarone-induced acute respiratory distress syndrome masquerading as acute heart failure.
The Journal of emergency medicine 2012 Nov;43;e311-4 2012 Nov
Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy.
Clinical research in cardiology : official journal of the German Cardiac Society 2008 Dec;97;917-20 2008 Dec
Possible association of pneumonitis with amiodarone therapy.
American heart journal 1980 Sep;100;412-3 1980 Sep

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