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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Isotretinoin

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 24/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

[Aggravation of asthma by isotretinoine].
Annales de dermatologie et de venereologie 2001 May;128;691 2001 May
Exacerbation of asthma by isotretinoin.
The British journal of dermatology 2000 Feb;142;388-9 2000 Feb
Bronchospasm induced by isotretinoin.
BMJ (Clinical research ed.) 1996 Apr 06;312;886 1996 Apr 06
Exercise-induced bronchoconstriction related to isotretinoin therapy.
Journal of the American Academy of Dermatology 1985 Sep;13;524 1985 Sep

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