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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
COVID19 (SARS-CoV2) vaccination/vaccine
5
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Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)
1
Last update :
14/07/2021
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Large-vessel vasculitis following the Pfizer-BioNTech COVID-19 vaccine.
Possible case of mRNA COVID-19 vaccine-induced small-vessel vasculitis.
Granulomatous vasculitis after the AstraZeneca anti-SARS-CoV-2 vaccine.