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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Abemaciclib

1

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 23/03/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
CDK4/6 inhibitors
1
Palbociclib
1
Ribociclib
1

Publications

Characteristics of interstitial lung disease in patients from post-marketing data on metastatic breast cancer patients who received abemaciclib in Japan.
Breast cancer (Tokyo, Japan) 2021 May;28;710-719 2021 May
Can CDK4/6 inhibitors cause fatal lung injury?
Expert review of anticancer therapy 2019 Nov;19;917-919 2019 Nov

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