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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiocontrast media (RCM)

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

3
Last update : 16/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Gadobutrol
2
Gadolinium-based MRI contrast media
2
Iodixanol
1
Iohexol
1

Publications

Anaphylactoid reactions to the nonvascular administration of water-soluble iodinated contrast media.
AJR. American journal of roentgenology 2015 Jun;204;1140-5 2015 Jun
Anaphylaxis: clinical patterns, mediator release, and severity.
The Journal of allergy and clinical immunology 2013 Nov;132;1141-1149.e5 2013 Nov
Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.
Allergy 2013 Jul;68;929-37 2013 Jul
Adverse reactions to iodinated contrast media: prevalence, risk factors and outcome-the results of a 3-year period.
Asian Pacific journal of allergy and immunology 2013 Dec;31;299-306 2013 Dec
Anaphylaxis: incidence, presentation, causes and outcome in patients in a tertiary-care hospital in Karachi, Pakistan.
QJM : monthly journal of the Association of Physicians 2013 Dec;106;1095-101 2013 Dec
Clinical pharmacology, uses, and adverse reactions of iodinated contrast agents: a primer for the non-radiologist.
Mayo Clinic proceedings 2012 Apr;87;390-402 2012 Apr
Anaphylaxis to radiographic contrast media.
Current opinion in allergy and clinical immunology 2011 Aug;11;326-31 2011 Aug
Epidemiologic and clinical features of anaphylaxis in Korea.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2008 Jan;100;31-6 2008 Jan
Fatal anaphylaxis: postmortem findings and associated comorbid diseases.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2007 Mar;98;252-7 2007 Mar
Anaphylactic deaths in Auckland, New Zealand: a review of coronial autopsies from 1985 to 2005.
Pathology 2006 Aug;38;328-32 2006 Aug
Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.
Drug safety 2005;28;547-56 2005
Elevated risk of anaphylactoid reaction from radiographic contrast media is associated with both beta-blocker exposure and cardiovascular disorders.
Archives of internal medicine 1993 Sep 13;153;2033-40 1993 Sep 13
Comparison of three pretreatment protocols to prevent anaphylactoid reactions to radiocontrast media.
Annals of allergy 1991 Jul;67;70-4 1991 Jul

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