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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interleukin 2 (IL2)

3

II.b ARDS - Acute lung injury

1
Last update : 14/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary toxicity of recombinant interleukin-2 plus lymphokine-activated killer cell therapy.
The European respiratory journal 1993 Jun;6;828-33 1993 Jun
Phase I trial of recombinant interleukin-2 followed by recombinant tumor necrosis factor in patients with metastatic cancer.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992 Feb;11;93-102 1992 Feb

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