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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interleukin 2 (IL2)

3

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 14/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Correlation between development of pulmonary edema and response of pulmonary metastases of metastatic melanoma and kidney cancer to high-dose continuous-infusion interleukin-2.
Cancer biotherapy & radiopharmaceuticals 2005 Apr;20;151-4 2005 Apr
Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer.
Cancer 1998 Aug 15;83;797-805 1998 Aug 15
Cytotoxic drug-induced pulmonary disease in infants and children.
Pediatric pulmonology 1994 Dec;18;347-55 1994 Dec
[Radiologic characteristics of the thorax during therapy with interleukin-2].
La Radiologia medica 1992 Oct;84;368-71 1992 Oct
Chest roentgenographic abnormalities in IL-2 recipients. Incidence and correlation with clinical parameters.
Chest 1992 Mar;101;746-52 1992 Mar
Pathogenesis of pulmonary edema during interleukin-2 therapy: correlation of chest radiographic and clinical findings in 54 patients.
AJR. American journal of roentgenology 1991 Feb;156;281-5 1991 Feb
Vascular leak syndrome associated with interleukin-2: chest radiographic manifestations.
Radiology 1990 Jul;176;191-4 1990 Jul
Pulmonary edema as a complication of interleukin-2 therapy.
AJR. American journal of roentgenology 1989 Apr;152;749-52 1989 Apr
Cardiopulmonary toxicity of adoptive immunotherapy.
The American journal of the medical sciences 1988 Dec;296;406-12 1988 Dec

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