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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interleukin 2 (IL2)

3

X.c Capillary leak syndrome (CLS)

2
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Acute and Chronic Cardiopulmonary Effects of High Dose Interleukin-2 Therapy: An Observational Magnetic Resonance Imaging Study.
Diagnostics (Basel, Switzerland) 2022 May 30;12; 2022 May 30
[Radiologic characteristics of the thorax during therapy with interleukin-2].
La Radiologia medica 1992 Oct;84;368-71 1992 Oct
Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer.
Blood 1991 Sep 15;78;1538-44 1991 Sep 15
Cardiorespiratory effects of immunotherapy with interleukin-2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 Jan;7;7-20 1989 Jan
Cardiopulmonary toxicity of adoptive immunotherapy.
The American journal of the medical sciences 1988 Dec;296;406-12 1988 Dec
Clinical effects and toxicity of interleukin-2 in patients with cancer.
Cancer 1986 Dec 15;58;2764-72 1986 Dec 15

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