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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Naphtalene (can be present in mothballs)

2

XIV.a Methemoglobinemia

2
Last update : 24/11/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Mothballs
2

Publications

Methemoglobinemia Secondary to a Traditional Healing Practice Using Mothballs: A Need of Pediatric Vigilance.
Cureus 2023 Jun;15;e41192 2023 Jun
Mothball Ingestion in the Setting of G6PD Deficiency Causing Severe Hemolytic Anemia, Methemoglobinemia, and Multiple Organ Failure in a Toddler.
Hawai'i journal of health & social welfare 2022 Jan;81;3-5 2022 Jan
Naphthalene Toxicity in Clinical Practice.
Current drug metabolism 2020;21;63-66 2020
Kerosene, Camphor, and Naphthalene Poisoning in Children.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2019 Dec;23;S278-S281 2019 Dec
Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular Hemolysis.
Cureus 2018 Aug 15;10;e3147 2018 Aug 15
Naphthalene ball poisoning: a rare cause of acquired methaemoglobinaemia.
BMJ case reports 2016 May 25;2016; 2016 May 25

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