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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

1
Last update : 17/02/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review.
Medicina (Kaunas, Lithuania) 2020 Apr 24;56; 2020 Apr 24
High incidence of tuberculosis in patients treated for hepatitis C chronic infection.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2016;20;205-9 2016
[Tuberculous peritonitis during pegylated interferon plus ribavirin combination therapy in a patient with chronic hepatitis C].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2014 Dec;111;2337-45 2014 Dec
Reactivation of severe, acute pulmonary tuberculosis during treatment with pegylated interferon-alpha and ribavirin for chronic HCV hepatitis.
Scandinavian journal of infectious diseases 2006;38;205-8 2006

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