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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Urticaria, angioedema and dyspnoea in adjuvant therapy of melanoma with interferon alpha-2b.
Acta dermato-venereologica 2010 May;90;308-9 2010 May
Severe exacerbation of asthma: a new side effect of interferon-alpha in patients with asthma and chronic hepatitis C.
Mayo Clinic proceedings 1999 Apr;74;367-70 1999 Apr

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