Pneumotox » Drug » Interferon alpha/beta » I.m - ILD with a granulomatous component

Interferon alpha/beta

Hepatic granulomas also described. Sarcoidosis may also develop in virus C hepatitis unexposed to interferon

Last update : 07/10/2012

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment