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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic hepatitis C.
World journal of gastroenterology 2010 Sep 21;16;4394-9 2010 Sep 21
Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature.
Digestive diseases and sciences 2010 Mar;55;579-85 2010 Mar
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.
Heart & lung : the journal of critical care 2008;37;153-6 2008
Severe interstitial pneumonitis secondary to pegylated interferon alpha-2b and ribavirin treatment of hepatitis C infection.
Digestive diseases and sciences 2004;49;1966-70 2004
Alpha-interferon induced severe pneumonitis.
Journal of toxicology. Clinical toxicology 1997;35;113-4 1997
Pneumonitis associated with natural and recombinant interferon alfa therapy for chronic hepatitis C.
Chest 1994 Mar;105;939-41 1994 Mar

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