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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

X.d Lupus - Lupus syndrome (see also Vd)

1
Last update : 21/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Systemic lupus erythematosus induced by interferon β1 therapy in a patient with multiple sclerosis.
Fundamental & clinical pharmacology 2012 Apr;26;210-1 2012 Apr
Drug-induced lupus erythematosus: incidence, management and prevention.
Drug safety 2011 May 01;34;357-74 2011 May 01
Anti-double stranded DNA and lupus syndrome induced by interferon-beta therapy in a patient with multiple sclerosis.
Lupus 2009 Jan;18;78-80 2009 Jan
Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.
Clinical rheumatology 2005 Apr;24;178-81 2005 Apr

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