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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

3
Last update : 04/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

High Risk of Infection During Triple Therapy with First-Generation Protease Inhibitors: A Nationwide Cohort Study.
Journal of gastrointestinal and liver diseases : JGLD 2016 Jun;25;197-204 2016 Jun
Diffuse Interstitial Pulmonary Infiltrates in Malignant Melanoma.
Respiratory care 2015 Jul;60;e115-7 2015 Jul
Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C.
The American journal of case reports 2014;15;235-8 2014
Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy.
Hepatology research : the official journal of the Japan Society of Hepatology 2013 Jul;43;801-7 2013 Jul
Cutaneous and pulmonary sarcoidosis following treatment of multiple sclerosis with interferon-β-1b: a case report.
Journal of medical case reports 2013 Dec 13;7;270 2013 Dec 13
Interferon-β-induced pulmonary sarcoidosis in a 30-year-old woman treated for multiple sclerosis: a case report.
Journal of medical case reports 2012 Oct 08;6;344 2012 Oct 08
Interferon-induced sarcoidosis with osseous involvement in a patient with melanoma.
Hellenic journal of nuclear medicine 2011;14;68-9 2011
Development of interferon induced sarcoidosis in a patient with familial mediterranean fever.
Tuberkuloz ve toraks 2008;56;319-24 2008
Interferon-induced sarcoidosis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2006 Oct;12;241-8 2006 Oct
Cutaneous, pulmonary and hepatic sarcoidosis associated with autoimmune complications during interferon-alpha treatment for hepatitis C virus infection.
Journal of the European Academy of Dermatology and Venereology : JEADV 2006 Apr;20;442-5 2006 Apr
Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases.
Medicine 2005 Mar;84;69-80 2005 Mar
Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma.
Cancer 1987 Mar 01;59;896-900 1987 Mar 01

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