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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

X.b Antiphospholipid antibodies w/wo the APL syndrome

1
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Drug-induced antiphospholipid syndrome: Analysis of the WHO international database.
Autoimmunity reviews 2022 May;21;103060 2022 May
The pathogenesis of the antiphospholipid syndrome.
The New England journal of medicine 2013 Jun 13;368;2334 2013 Jun 13
Anti-PL7 antisynthetase syndrome under interferon therapy.
Joint bone spine 2011 Jan;78;94-7 2011 Jan

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