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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Infliximab
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Sarcoid-like granulomatosis (endo-/extrathoracic)
2
Last update :
26/11/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
Infliximab biosimilar
TNF-alpha antagonists / inhibitors
Publications
Sarcoidosis associated with infliximab therapy in ulcerative colitis: A case report.
Tumour necrosis factor (TNF) inhibitor-induced isolated pleural granulomas: a rare adverse effect.
Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases.