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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

2
Last update : 26/11/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Sarcoidosis associated with infliximab therapy in ulcerative colitis: A case report.
Medicine 2017 Mar;96;e6156 2017 Mar
Tumour necrosis factor (TNF) inhibitor-induced isolated pleural granulomas: a rare adverse effect.
BMJ case reports 2017 Jun 18;2017; 2017 Jun 18
Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases.
Rheumatology (Oxford, England) 2009 Aug;48;883-6 2009 Aug

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