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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Drug-induced lupus erythematosus presenting with cardiac tamponade: a case report and literature review.
The Canadian journal of cardiology 2014 Feb;30;247.e11-2 2014 Feb
Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.
The American surgeon 2012 Dec;78;1406-8 2012 Dec
Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic.
Mayo Clinic proceedings 2009 Nov;84;979-84 2009 Nov
Tumor necrosis factor-alpha inhibitor-induced lupus-like syndrome presenting as fever of unknown origin in a liver transplant recipient: case report and concise review of the literature.
Transplantation proceedings 2008 Jun;40;1768-70 2008 Jun
Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.
Medicine 2007 Jul;86;242-251 2007 Jul
Infliximab-induced SLE-like syndrome involving the lung and pleura.
Lupus 2007;16;764-6 2007
Drug-induced lupus after treatment with infliximab in rheumatoid arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2005 Feb;11;47-9 2005 Feb

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